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KMID : 0370220050490030205
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Yakhak Hoeji
2005 Volume.49 No. 3 p.205 ~ p.211
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Frequent Changes of 3’ UTR Sequences in the Genes Expressed During Hematopoietic Differentiation Implicates the Importance of 3’ UTR in Regulation of Gene Function
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강승이/Kang SY
오수아/이학성/한성태/신차균/Oh SA/Lee HS/Han ST/Shin CG
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Abstract
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The 3’ UTR(3’ untranslated region) plays important roles in controlling gene expression through regulating 3’ polyadenylation, mRNA export, subcellular localization, translational efficiency, and mRNA stability. Changes in the 3’ UTR sequence in an expressed transcript can result in functional changes of the genes that are expressed in pathological conditions compared with those genes expressed in normal physiologic conditions. A genome-wide survey of 3’ UTR variation was performed for the genes expressed during hematopoietic differentiation from CD34+ stem/progenitor cells to CD15+ myeloid progenitor cells. Wide-spread differential usage of the 3’ UTR was observed from the genes expressed during this celluar transition. This study implies that the 3’ UTR can be a highly coordinated region for post-transcriptional regulation of the function of expressed genes.
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